![]() ![]() POB is an investigator for the Howard Hughes Medical Institute. ![]() This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This work was supported mainly by the Howard Hughes Medical Institute and by a grant from the Canary Foundation. Received: MaAccepted: JPublished: September 5, 2013Ĭopyright: © 2013 Salzman et al. Moran, University of Michigan, United States of America The ubiquity of circular RNA and its specific regulation could significantly alter our perspective on post-transcriptional regulation and the roles that RNA can play in the cell.Ĭitation: Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO (2013) Cell-Type Specific Features of Circular RNA Expression. ![]() In humans, we estimate that circular RNA may account for about 1% as many molecules as poly(A) RNA. Here, we show that the repertoire of genes expressing circular RNA, the relative levels of circular: linear transcripts from each gene, and even the pattern of splice isoforms of circular RNAs from each gene were cell-type specific, including examples of striking regulation. An almost universal characteristic of regulatory macromolecules is that they are themselves regulated during development and differentiation. Previous novel RNA species that initially appeared to be special cases, of dubious biological significance, have subsequently proved to have critical, conserved biological roles. Last year, we reported that circular RNA isoforms, previously thought to be very rare, are actually a pervasive feature of eukaryotic gene expression programs indeed, the major RNA isoform from hundreds of human genes is a circle. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |